The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis. Expression of the CB1 and CB2 receptor messenger RNAs during embryonic development in the rat. Cannabinoid receptor agonist efficacy for stimulating GTPγS binding to rat cerebellar membranes correlates with agonist-induced decreases in GDP affinity. The endocannabinoid anandamide is a direct and selective blocker of the background K(+) channel TASK-1.
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Circuitry for associative plasticity in the amygdala involves endocannabinoid signaling. A role for caveolae/lipid rafts in the uptake and recycling of the endogenous cannabinoid anandamide. RNA interference suggests a primary role for monoacylglycerol lipase in the degradation of the endocannabinoid 2-arachidonoylglycerol. Molecular characterization of human and mouse fatty acid amide hydrolases. Modulation of cannabinoid agonist binding by 5-HT in the rat cerebellum.
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The synthesis and pharmacological evaluation of the what does CBD do? cannabinoid antagonist SR141716A. Cannabidiol, a non-psychoactive component of cannabis and its synthetic dimethylheptyl homolog suppress nausea in an experimental model with rats.
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The endogenous cannabinoid system and its role in nociceptive behavior. In conclusion, OEA is a new orally active anorectic agent that may possess potential as a new antiobesity drug. These results strongly suggest that the anorectic effect of Δ9-THC shown by many previous reports was indirectly due to the sedated state induced by high doses of the drug. 189) reported that an interaction between progesterone and dopamine receptor type 1 is required for Δ9-THC-facilitated sexual receptivity in female rats.
Cannabinoid system as a potential target for drug development in the treatment of cardiovascular disease. Evaluation of CB1 receptor knockout mice in the Morris water maze.
The preimplantation mouse embryo is a target for cannabinoid ligand-receptor signaling. Specific inhibition of FSH-stimulated cAMP accumulation by Δ9-tetrahydrocannabinol in cultured rat granulosa cells. Anandamide activity and degradation are regulated by early postnatal aging and follicle-stimulating hormone in mouse Sertoli cells. Potential modulation of plasma ghrelin and glucagon-like peptide-1 by anorexigenic cannabinoid compounds, SR141716A and oleoylethanolamide. Expression and regulation of leptin receptor proteins in afferent and efferent neurons of the vagus nerve.